Web Analytics

Uncategorized

Ford’s Hemp Car That Never Reached Production

Ford’s Hemp Car That Never Reached Production by Aaron Cadena at CBD Origin The Model T and Ford’s Hemp Car In 1904, Henry Ford founded the Ford Motor Company and, by October 1908, he released the Model T, revolutionizing the automotive industry forever. While the story of Ford’s rise to success with the Model T has been popularized throughout American culture, one of his most revolutionary accomplishments was kept in the dark. In 1941, shortly after launching the first Ford V8, Henry Ford [...]

Read more...

FDA Hearing Leads to Decline in Cannabis Stocks

FDA Hearing Leads to Decline in Cannabis Stocks by Ryan Tengco at CBD Origin Investors in cannabis companies were in for a rude awakening after the recent FDA hearing on the regulation CBD products, as stocks briefly declined. Up until the FDA hearing last month, market analysts and CBD business owners had hoped for further direction from the FDA on approving CBD as a food product, label regulations, and other pertinent topics; however, the obscurity of the hearing has left many [...]

Read more...

Ben & Jerry’s Preps CBD Ice Cream Release

Ben & Jerry’s Preps CBD Ice Cream Release by Aaron Cadena at CBD Origin Even before the FDA hearing on CBD regulation last Friday, May 31, 2019, renowned ice cream maker, Ben & Jerry’s, announced the possible release of their already infamous CBD-infused ice cream. Based on the company’s public announcement, playfully titled, “CBD Ice Cream Is (Maybe, Hopefully) Coming To A Freezer Near You!”, their newest creation will release as soon as the legal complications surrounding CBD are resolved. By releasing [...]

Read more...

Green Flash Chromatography Webinar

Over the past several decades, the chemical industry has implemented process changes and updated practices in R&D and manufacturing in an effort to reduce liquid and solid lab waste. The pharmaceutical industry in particular has taken steps within their drug discovery labs to reduce solvent use by requiring their chemists to find and implement measures that achieve the corporate environmental goals without curtailing their productivity – quite the challenge. Learn More Here!

Read more...

France Moves to Legalize Cannabis for Medical Studies

France Moves to Legalize Cannabis for Medical Studies by Ryan Tengco at CBD Origin In a recent, groundbreaking decision, France’s Senate has approved a proposal to legalize medical cannabis. Since the proposal was passed on May 28th, the French government has made plans to adopt a two-year period of experimental studies on the outcomes of medical cannabis use. According to the proposal, the French Government plans to only cultivate certain breeds of Cannabis that produce very low amounts of THC and high [...]

Read more...

How can I reduce flash column purification time and cost?

This is a question being asked of my colleagues and me more and more frequently, especially in pharma accounts.  Why?  Well, you are familiar with the adage – Time is Money, right.  Well this really applies to them. A new molecular entity (NME) created as a pharmaceutical can take up to a decade and a billion dollars to bring to market.  Granted, the biggest costs are in the clinical trials but the synthetic route and the time to discover [...]

Read more...

Illinois Legalizes Cannabis, Bill to Become Law in January 2020

Illinois Legalizes Cannabis, Bill to Become Law in January 2020 by Ryan Tengco at CBD Origin Last Friday, May 31, 2018, marked a monumental day as Illinois legalizes Cannabis, which made Illinois the 11th state to legalize recreational marijuana in the United States. The Bill which was backed by Illinois Governor J.B. Pritzker (D) was passed in the Illinois House of Representatives in Springfield by a vote of 66-47. This comes just two days after the Illinois State Senate also passed the [...]

Read more...

Flash column chromatography equilibration speed – how fast can you go?

Equilibrating silica flash chromatography columns is something I always do.  There are chemists who see this as an unnecessary, time-and-solvent-wasting step.  Because getting consistent, predictable results is a priority, I equilibrate to remove the variability that can be caused by heat generated as solvent initially contacts the silica. Consistency is really important when running flash column chromatography because re-runs are time consuming and may put your compound at risk. In this post, I examine the role of equilibration speed and [...]

Read more...

How can I perform normal-phase and reversed-phase column chromatography on one flash system?

For chemists, flash chromatography is part of their everyday synthesis workflow. For most syntheses, crude reaction mixtures are purified by normal-phase (aka adsorption) chromatography.  There are times; however, where the crude mixture’s complexity and polarity make normal-phase chromatography very challenging.  For these situations, reversed-phase (aka partition) chromatography may be a preferred option. But, if you have only one flash system available, can you, should you, and how do you efficiently switch from non-polar, normal-phase solvents to polar, reversed-phase solvents – and [...]

Read more...

How do particle size and flow rate affect normal-phase flash column chromatography?

Media particle size and solvent flow rate play major roles in chromatographic separations including flash purification.  This is true in both reversed-phase chromatography (aka partition chromatography) as well as normal-phase chromatography. The roles played are related to the overall compound mass-transfer kinetics and diffusion/dispersion as they migrate through the column.  Smaller particles reduce sample dilution by reducing interstitial volume, while flow rate impacts the ability of molecules to efficiently pass through the porous particles. In this post, I will show how [...]

Read more...